The Membrane Attack Complex/Perforin Superfamily
نویسندگان
چکیده
منابع مشابه
The membrane attack complex, perforin and cholesterol-dependent cytolysin superfamily of pore-forming proteins.
The membrane attack complex and perforin proteins (MACPFs) and bacterial cholesterol-dependent cytolysins (CDCs) are two branches of a large and diverse superfamily of pore-forming proteins that function in immunity and pathogenesis. During pore formation, soluble monomers assemble into large transmembrane pores through conformational transitions that involve extrusion and refolding of two α-he...
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The membrane attack mechanism of complement, C5 to C9, has previously been postulated to associate on the target cell surface to a stable decamolecular complex with a calculated mol wt of 995,000. A soluble and stable complex consisting of C5, C6, C7, C8, and C9 has now been demonstrated to arise as a consequence of complement activation by the classical or alternate pathway. It has a sedimenta...
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ژورنال
عنوان ژورنال: Journal of Molecular Microbiology and Biotechnology
سال: 2017
ISSN: 1464-1801,1660-2412
DOI: 10.1159/000481286